Having anxiety about aging, particularly fears concerning declining health, may manifest at a cellular level and contribute to accelerated aging among women. This is the conclusion of a study conducted by researchers at NYU School of Global Public Health.
“Our research suggests that subjective experiences may be driving objective measures of aging,” said Mariana Rodrigues, a PhD student at NYU School of Global Public Health and the first author of the study, published in the journal Psychoneuroendocrinology. “Aging-related anxiety is not merely a psychological concern, but may leave a mark on the body with real health consequences.”
Anxiety and Its Biological Impact
Many individuals experience stress about aging, worrying about physical decline, illness, and a loss of independence. Moreover, research indicates that psychological distress can contribute to biological aging through epigenetic changes, which are alterations in how genes are expressed.
“We know from previous research that anxiety, depression, and mental health in general are associated with a number of physical health outcomes, but until now researchers haven’t focused on whether there is a correlation between worrying about aging and the process of aging itself,” Rodrigues explained.
Women, in particular, may have heightened anxiety about aging due to cultural norms emphasizing youth and beauty, as well as concerns about declining fertility. “Women in midlife may also be juggling multiple roles, including caring for aging parents. As they see older family members grow older and become sick, they may worry about whether the same thing will happen to them,” added Rodrigues.
Study Insights and Methodology
To better understand the relationship between anxiety about aging and aging itself, the researchers analyzed data from 726 women who participated in the Midlife in the United States (MIDUS) study. Participants were asked about their concerns regarding becoming less attractive with age, experiencing more health issues, and being too old to have children.
The study also involved collecting blood samples to measure aging using two “epigenetic clocks”: DunedinPACE, which captures the pace of biological aging, and GrimAge2, which estimates cumulative biological damage.
Having greater anxiety about growing old was associated with accelerated epigenetic aging, as measured by the DunedinPACE epigenetic clock.
These biological changes could potentially contribute to physical decline and increased vulnerability to aging-related diseases. Worrying about declining health had the strongest associations with epigenetic aging, while anxiety about declining attractiveness and fertility were not significantly associated with epigenetic aging. This may be because health-related concerns are more common and persist over time, while worries about beauty and reproductive health may fade with age.
Implications and Future Research
According to the researchers, the study serves as a reminder that mental and physical health across the lifespan are intimately connected, despite often being treated as separate entities. “Our research identifies aging anxiety as a measurable and modifiable psychological determinant that seems to be shaping aging biology,” said Adolfo Cuevas, associate professor of social and behavioral sciences at NYU School of Global Public Health and the study’s senior author.
The researchers also noted that the study, which provides a snapshot of aging anxiety and biomarkers at one point in time, cannot rule out that other factors may be influencing these biological changes. Harmful health behaviors often used to cope with anxiety may help to explain the link between aging anxiety and accelerated aging. When the researchers adjusted their analyses to control for health behaviors like smoking and alcohol use, the association between aging anxiety and epigenetic aging decreased and was no longer significant.
More studies are needed to clarify how this type of anxiety influences aging over time, which could help health professionals determine how to best support those experiencing aging anxiety and mitigate related harm.
“Aging is a universal experience,” said Rodrigues. “We need to start a discourse about how we as a society—through our norms, structural factors, and interpersonal relationships—address the challenges of aging.”
Jemar R. Bather of NYU School of Global Public Health was a study coauthor. The research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK137246, R01DK137805).
